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Bromazepam (Lexotanil) is in the group of drugs known as benzodiazepines, a class of antidepressants, anti-panic agents, and muscle relaxants. It is used for the short-term relief of symptoms of excessive anxiety, nervousness and tension.
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Buy Bromazepam Online (marketed under several brand names, including Lectopam, Lexotan, Lexilium, Lexaurin, Brazepam, Rekotnil, Bromaze and Lexotanil) is a benzodiazepine derivative drug, patented by Roche in 1963 and developed clinically in the 1970s. It has mainly anxiolytic properties and at higher doses also sedative, hypnotic and skeletal muscle relaxant properties.

INDICATIONS

For the short-term treatment of insomnia, short-term treatment of anxiety or panic attacks, if a benzodiazepine is required, and the alleviation of the symptoms of alcohol- and opiate-withdrawal. Premedication to alleviate anxiety before surgery.

Biotransformation

Hepatically, via oxidative pathways (via an enzyme belonging to the Cytochrome P450 family of enzymes).

Absorption

Bioavailability is 84% following oral administration.

Half-Life

10-20 hours.

SIDE EFFECTS

Bromazepam 3 times 6 mg daily for 2 weeks taken alone impaired learning capacities significantly in humans in an experiment. In combination with alcohol, the impairments of learning capacity became even more pronounced. Impairments to memory functions are common with bromazepam and include reduced working memory and reduced ability to process environmental information. Impaired memory, visual information processing, and sensory data and impaired psychomotor performance.
Deterioration of cognition including attention capacity and impaired co-ordinative skills. Impaired reactive and attention performance, which can impair driving skills.
The most common side-effects of benzodiazepines are related to his sedating and muscle-relaxing action. They include drowsiness, dizziness, and decreased alertness and concentration. Lack of coordination may result in falls and injuries, in particular, in the elderly.

Another result is the impairment of driving skills and increased likelihood of road traffic accidents. Decreased libido and erection problems are a common side effect. Depression and disinhibition may emerge. Hypotension and suppressed breathing may be encountered with intravenous use.

Paradoxical effects

Paradoxical reactions, such as increased seizures in epileptics, aggression, violence, impulsivity, irritability and suicidal behavior sometimes occur. These reactions have been explained as consequences of disinhibition and the subsequent loss of control over socially unacceptable behavior. Paradoxical reactions are rare in the general population, with an incidence rate below 1% and similar to placebo.

However, they occur with greater frequency in recreational abusers, individuals with a borderline personality disorder, children, and patients on high-dosage regimes. In these groups, impulse control problems are perhaps the most important risk factor for disinhibition; learning disabilities and neurological disorders are also significant risks. Most reports of disinhibition involve high doses of high-potency benzodiazepines. Paradoxical effects may also appear after chronic use of bromazepam.

Cognitive effects

The short-term use of benzodiazepines adversely affects multiple areas of cognition, the most notable one being that it interferes with the formation and consolidation of memories of new material and may induce complete anterograde amnesia. However, researchers hold contrary opinions regarding the effects of long-term administration. One view is that many of the short-term effects continue into the long-term and may even worsen, and are not resolved after quitting benzodiazepines. Another view maintains that cognitive deficits in chronic benzodiazepine users occur only for a short period after the dose, or that the anxiety disorder is the cause of these deficits.

Long-term effects

Adverse effects of chronicbromazepam use can include cognitive impairment as well as effective and behavioral problems. Feelings of turmoil, difficulty in thinking constructively, loss of sex-drive, agoraphobia and social phobia, increasing anxiety and depression, loss of interest in leisure pursuits and interests, and an inability to experience or express feelings can also occur. Additionally, an altered perception of self, environment, and relationships may occur.

Other effects

Very rarely dystonia can develop.
Leukopenia and liver-damage of the cholestatic type with or without jaundice (icterus) have additionally been seen.
Up to 30% treated on a long-term basis develop a form of dependence, i.e. these patients cannot stop the medication without experiencing physical and/or psychological benzodiazepine withdrawal symptoms.
Ambulatory patients should be warned that Bromazepam may impair the ability to drive vehicles and to operate machinery. The impairment is worsened by the consumption of alcohol because of both act as central nervous system depressants. During the course of therapy, tolerance to the sedative effect usually develops.
Less common side effects include nausea and changes in appetite, blurred vision, confusion, euphoria, depersonalization, and nightmares. Cases of liver toxicity have been described but are very rare.

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